New study links melatonin and heart failure, but experts say don’t panic yet

New Study Links Melatonin and Heart Failure

A recent study analyzed health records of tens of thousands of adults with chronic insomnia and found that those who took prescribed melatonin for over a year had a higher risk of developing heart failure within five years compared to nonusers, the American Heart Association reported Monday.

The researchers also observed that melatonin users were more likely to be hospitalized for heart failure and had a higher all-cause mortality than those not using the supplement.

Expert Reactions and Cautions

However, the study has not yet undergone peer review and has received mixed responses from sleep medicine specialists and cardiologists. Experts advise the public not to make sudden changes based on these findings and emphasize the need for further research on long-term melatonin use.

The preliminary results appear to contradict previous research indicating potential health benefits of melatonin for individuals with heart failure.

Presentation and Context

This research abstract is slated for presentation at the American Heart Association’s Scientific Sessions, a conference focused on advances in cardiovascular science and medicine.

Disclosure

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Experts urge people and health care providers not to make drastic changes despite a study linking melatonin and heart failure.

Author’s summary: Early findings suggest a possible link between long-term melatonin use and heart failure risk, but experts emphasize caution and call for more rigorous research before drawing conclusions.

Toronto Sun — 2025-11-06