Melatonin users have 90% higher chance of developing heart failure, twice as likely to die: New study

Melatonin Use Linked to Increased Heart Failure Risk

A recent study presented at the American Heart Association Scientific Sessions 2025 shows that adults with insomnia who use melatonin supplements for over a year face a significantly higher risk of developing heart failure.

Key Findings from the Study

Long-term melatonin users had a 90% greater chance of developing heart failure compared to non-users.
These individuals were also nearly 3.5 times more likely to be hospitalized due to heart failure.
They faced an increased risk of death from any cause within five years following melatonin use.

Study Details

Researchers analyzed health records of more than 130,000 adults with insomnia and no prior heart failure history. The study compared outcomes between those using melatonin for at least one year and those who never used it.

Melatonin Use and Prescription Differences

In the United States, melatonin is widely available over the counter, with nearly six million Americans using it to improve sleep. However, in the United Kingdom, melatonin is prescription-only.

Among UK patients who filled at least two melatonin prescriptions 90 days apart, the risk of developing heart failure rose by 82%.

"Adults with insomnia who took melatonin for at least a year had a much higher chance of developing heart failure." – Study presented at AHA Scientific Sessions 2025

Implications

While melatonin helps many fall asleep faster or sleep longer, this new evidence suggests caution around its long-term use, especially in adults with insomnia.

Summary

Long-term melatonin use in adults with insomnia is associated with nearly double the risk of heart failure and higher likelihood of hospitalization or death within five years, highlighting potential risks of prolonged use.

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Mint — 2025-11-07